Hello,
For anyone having the problem with Spine and Comodo, I found how to exclude it from comodo without having to uninstall.:

I added it in many classic exclusion list (like antivirus and firewall exclusion - full folder + .exe), but it seems that this last place (which is a litle "hidden") was the one that unblocked me :

Advanced protection > Misc > Do not detect injection of command in the following applications > add the Spine path.

Here you can see in screenshot that I manage to open application.
Sorry interface is in french, but you can adapt to your langage.

I hope it helps
(at least it will help me in the future because I already found it years ago and struggle again for two days after system reinstall xD)