I'm having the exact same issue. If I set the "Scale" on my SkeletonData to around 0.003 it seems to be about right.
With the previous Spine Runtime, the one that had special tk2d support as a separate folder of code, it worked properly with my SkeletonData scale at 1. Is there a fix for this coming? As it is right now, it's unusable.
Also, as a small aside, there's a bug on line 110 of SkeletonDataAsset.cs, there's a semicolon missing at the end of the line. This is in the code that comes with the current unitypackage for the Spine Unity Runtime, I just downloaded it tonight. It's only an issue if you enable tk2d support, as that code is in an "#if SPINE_TK2D" section.
As an aside: thanks for a great piece of software - my animator is really enjoying Spine, and the workflow with tk2d is really slick, it works great! 🙂
Update: making the change noted by bang2ni (removing the "* 100") fixes everything. If it's not needed, can that be updated in the official release so that it doesn't cause issues for anyone else?