Hello,
It seems that there is some issue with the editing of shortcuts on OSX
Also, changing the keyboard to AZERTY doesn't seem to be saved correctly ( the "*" stay there even after an apply and restart ). I'm not sure though
After editing the shortcut.txt, random errors appear at startup, telling me that multiple shortcut lines are using the same code.
Could you send us your shortcut config file?
Here the log + the shortcut file
"Spine Launcher 4.0.36
Esoteric Software LLC (C) 2013-2021 | http://esotericsoftware.com
Mac OS X x86_64 11.2
Apple, Apple M1, 2.1 Metal - 71.0.7
Downloading: Spine 4.0.04 Professional
Starting: Spine 4.0.04 Professional
Spine 4.0.04 Professional
Licensed to: *****, *****
ERROR: Error reading hotkeys file: /Users/funshark/Library/Application Support/Spine/settings/hotkeys-1.txt
Duplicate actions for SEMICOLON: Set Loop End, Color
Started.
OpenAL 1.1, Default audio device
"
The error message shown in your log is:
Duplicate actions for SEMICOLON: Set Loop End, Color
Your hotkeys file has these two entries:
Color: SEMICOLON
Set Loop End: SEMICOLON
You can't have two hotkeys use the same shortcut. By default, with QWERTY, the entries are:
Color: M
Set Loop End: RIGHT_BRACKET
Did you change them to SEMICOLON, or are you saying they were changed automatically, possibly when choosing AZERTY?
Yeah I know it can't have two same entries 
But If I correct these, another one pop right after.
And yes, these errors appears after editing the hotkeys.txt and maybe after selecting the AZERTY
The initial problem was that the AZERTY option didn't seem to do anything ( on OSX ) and even after modifying the hotkeys.txt, the shortcuts weren't taken into consideration ( on 1 computer )
I fixed the "weren't taken into consideration" part on my computer with the removal of duplicate hotkeys.txt and old saves (?) and then got the semicolon error.
However, on my coworker osx, the shortcuts still don't work ( last time I've checked with him )