Mitch, you're the man, and you know it.
@davidsvson I concur with Pharan. For instance, I'm currently working on a 2D point and click adventure using Spine. Mecanim is not as suited for this since in our case things as speed or velocity to determine animation states are not fundamental.
Mitch showed it tome using one of his platformer examples though, and you'll find it's perfect for those cases.